Yellow Nail Syndrome (YNS) was first described by London physicians Peter Samman and William White in 1964. The nail changes are characterized by marked thickening and yellow to yellowish green nail discoloration which is often associated with systemic disease, most commonly lymphedema (80%) and lung disease. The nails are typically over curved in both transverse… Read more »
Proteus Syndrome is also known as Elattoproteus Syndrome and elephant man disease. It may be confused with Neurofibromatosis and the Elephant Man, Joseph Merrick, originally believed to have neurofibromatosis, is now believed to have had Proteus Syndrome. To see images of Joseph Merrick click HERE. In 1983 a German pediatrician named the syndrome after the… Read more »
Sweet’s syndrome is a rare paraneoplastic syndrome, usually associated with hematologic malignancies, manifesting with fevers, neutrophilic leucocytosis, painful edematous plaques, usually involving the hands and distal arms with a dermal infiltrate of neutrophils on biopsy. One of the characteristic features of Sweet’s is what is called “pseudovesiculation”…the cutaneous lesions appear to be vesicles, however, if… Read more »