Sweet’s syndrome is a rare paraneoplastic syndrome, usually associated with hematologic malignancies, manifesting with fevers, neutrophilic leucocytosis, painful edematous plaques, usually involving the hands and distal arms with a dermal infiltrate of neutrophils on biopsy. One of the characteristic features of Sweet’s is what is called “pseudovesiculation”…the cutaneous lesions appear to be vesicles, however, if… Read more »
Fixed drug eruptions are common and manifest as edematous plaques in the same sites within 30 minutes to 8 hours of ingestion of the offending medication. Frequently these medications are taken intermittently and include non-steroidal anti-inflammatory drugs (pyrazolone derivatives, paracetamol, naproxen, oxicams and mefenamic acid), sulfonamides, and trimethoprim are frequent offenders. Additional agents include barbiturates,… Read more »