Fixed drug eruptions are common and manifest as edematous plaques in the same sites within 30 minutes to 8 hours of ingestion of the offending medication. Frequently these medications are taken intermittently and include non-steroidal anti-inflammatory drugs (pyrazolone derivatives, paracetamol, naproxen, oxicams and mefenamic acid), sulfonamides, and trimethoprim are frequent offenders. Additional agents include barbiturates, tetracyclins, fluconazole, fluoroquinoloones, phenolphthalein, acetaminophen (tylenol), citrizine, clecoxib, dextromethorphan, hydroxyzine (atarax), quinine, lamotrigine, phenylporopanolamine, erythromycin and Chinese and Japanese herbs.
Many of these medications can cause even more severe reactions…LINK.
To read more about fixed drug eruptions click HERE.