Andrew and I recently published a series in the Journal of the American Academy of Dermatology of patients that appear to have eruptive angiomas associated with the use of an asthma drug–Ipratropium Bromide. To read this article click HERE. I thought it would be good to show some additional photographs and demonstrate the histology… Read more »
Dilantin & Radiation Associated Toxic Epidermal Necrolysis (TEN): This is a patient at Walter Reed Army Medical Center. The patient had metastatic breast cancer to her brain and was experiencing severe seizures. She was treated with Dilantin to control the seizures. Treatment at the time included cranial radiation. We were asked to see her when… Read more »
Sweet’s syndrome is a rare paraneoplastic syndrome, usually associated with hematologic malignancies, manifesting with fevers, neutrophilic leucocytosis, painful edematous plaques, usually involving the hands and distal arms with a dermal infiltrate of neutrophils on biopsy. One of the characteristic features of Sweet’s is what is called “pseudovesiculation”…the cutaneous lesions appear to be vesicles, however, if… Read more »
Fixed drug eruptions are common and manifest as edematous plaques in the same sites within 30 minutes to 8 hours of ingestion of the offending medication. Frequently these medications are taken intermittently and include non-steroidal anti-inflammatory drugs (pyrazolone derivatives, paracetamol, naproxen, oxicams and mefenamic acid), sulfonamides, and trimethoprim are frequent offenders. Additional agents include barbiturates,… Read more »